The search leads to the viewing of the evolutionary patterns of domains as the results from Protein-Domain Profiling, a procedure that orders proteins and domains in the entire proteome by hierarchical clustering based on domain compositions/linkages. Specifically, seven eukaryotic species, namely S. cerevisiae (yeast), D. discoideum (slime mold), C. elegans (nematode worm), D. melanogaster (fly), D. rerio (fish), G. gallus (chicken) and H. sapiens (human), were amalgamated into a combined protein set, with which profiling were performed using 623 domains based on annotations from the SMART database.
Please cite the following reference for this website:
Jin et al. (2009) Eukaryotic Protein Domains as Functional Units of Cellular Evolution  Sci. Signal.Vol. 2, Issue 98, p. ra76   [PubMed]
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Website Contributors: Jin Gyoon Park, Marina Olhovsky, Xueying Xie, Yongyi Mao, Jing Jin, Tony Pawson
Pawson Laboratory, Samuel Lunenfeld Research Institute, Mount Sinai Hospital Toronto, ON, Canada