In the Pawson lab, our focus is on studying the mechanisms that underlie intracellular signal transduction. Modular protein domains that mediate protein-protein interactions are critical elements of this process. These modules are typified by the phosphotyrosine binding Src homology 2 (SH2). Since the discovery of SH2 domains, the number of different modules has grown into the dozens, many of which we continue to investigate. Work on the molecular dissection and functional significance of protein-protein interactions, in signal transduction, is a primary focus of the lab. In addition to this, we are also actively working on the molecular signals involved in axon guidance; wiring the cell through protein interactions especially Eph receptors and ephrins.

 Tony Pawson's Kyoto Prize Commemorative Lecture in Kyoto Japan [Kyoto Prize Link] [Lecture]