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 TUDOR Domain | |
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Structure:
 The three-dimensional structure of the Tudor domain of human SMN forms a strongly bent anti-parallel beta-sheet consisting five beta-strands that form a barrel-like fold. Several amino acids residues stabilize the SMN Tudor domain structure through formation of a hydrophobic core and are conserved among other Tudor domain sequences suggesting that other Tudor domains possess a similar three-dimensional fold. Interestingly, the structure of the SMN Tudor domain resembles the fold of the Sm core proteins despite an absence of any amino acid sequence similarity.
Structure Reference:Huang, Y. et al. (2006) Science. 312(5774): 748-51. PDB: 2GFA. | |
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Domain binding and function:
The Tudor domain was originally identified as a region of 50 amino acids found in the Tudor protein (a posterior group gene) encoded in Drosophila. The three-dimensional structure of the Tudor domain of human SMN forms a strongly bent anti-parallel β-sheet consisting of five β-strands with a barrel-like fold. It was subsequently found among other proteins to be involved in binding RNA. Two additional Tudor domain containing proteins, 53BP1 and JMJD2A contain either tandem or double Tudor domains with distinct folds despite sequence similarity. The unusual folds of these proteins are required for its ability to recognize methylated histones.
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Examples of Proteins:
| TUDOR domain proteins | Binding Partner
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| SMN | methylated RG repeats of Sm proteins |
| 53BP1 | methylated H4-K20
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JMJD2A
| methylated H3-K4, H4-K20
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Referenced in part on Cell Signaling Technology Website, Reference Section on Protein Domains. We gratefully acknowledge the following contributors:
Piers Nash1, Dan Lin3, Kathleen Binns2, Clark Wells2, Rob Ingham2, Terry Kubiseski2, Bernard Liu1, Matt Smith2,3, Ivan Blasutig2,3, Maria Sierra1, Caesar Lim2,3, Michael Arc1, Jim Fawcett2 and Tony Pawson2,3.
1. Ben May Institute for Cancer Research, The University of Chicago, Chicago, Illinois, 60637, USA
2. Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
3. Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
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