 CALM Domain | |
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Class:Phospholipid binding
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Structure:
“The CALM/ANTH domain of AP180 bound to PtdIns(4,5)P2”
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Domain binding and function:
The CALM (Clathrin Assembly Lymphoid Myeloid) domain, also known as ANTH, conforms to a structure similar to the ENTH domain with the addition of one or more α-helix. Although both CALM/ANTH and ENTH domains bind PtdIns(4,5)P2 with high specificity, they differ in the manner in which they bind. ENTH domains bind PtdIns(4,5)P2 in a pocket whereas ANTH domains doe not have a well defined binding pocket but instead uses surface exposed basic residues to coordinate the ligand. CALM/ANTH domain proteins include AP180 and CALM that are implicated in the formation of clathrin-coated pits.
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Examples of Proteins:
| CALM proteins |
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Binding Partner |
| AP180 |  |
PtdIns(4,5)P2 |
| CALM (AP180-2) | |
PtdIns(4,5)P2 |
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Referenced in part on Cell Signaling Technology Website, Reference Section on Protein Domains. We gratefully acknowledge the following contributors:
Piers Nash1, Dan Lin3, Kathleen Binns2, Clark Wells2, Rob Ingham2, Terry Kubiseski2, Bernard Liu1, Matt Smith2,3, Ivan Blasutig2,3, Maria Sierra1, Caesar Lim2,3, Michael Arc1, Jim Fawcett2 and Tony Pawson2,3.
1. Ben May Institute for Cancer Research, The University of Chicago, Chicago, Illinois, 60637, USA
2. Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
3. Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
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