 PWWP Domain | |
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| Class:Other | |
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Structure:
“PWWP Domain of Mammalian Dnmt3b”
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Domain binding and function:
The PWWP domain was first identified upon characterizing a gene located in the Wolf-Hirschhorn syndrome (WHS) critical region. The translocated form of WHSC1 is involved in lymphoid multiple myeloma (MM) disease, also known as plasmacytoma. The domain was designated PWWP based on its central core ‘proline-tryptophan-tryptophan-proline’. Identified in some two-dozen proteins in the human genome, the PWWP domain is ~135 amino acid residues in length. The N-terminal half of the PWWP domain exhibits a barrel-like five-stranded structure that resembles the SAND domain, while the C-terminal portion is made up of a five-helix bundle. PWWP domains are found in eukaryotic proteins from yeast to mammals and are involved in DNA methylation, DNA repair and regulation of transcription. The PWWP domain of Dnmt3b2 contains a basic surface that may play a role in DNA binding.
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Examples of Proteins: 
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Referenced in part on Cell Signaling Technology Website, Reference Section on Protein Domains. We gratefully acknowledge the following contributors:
Piers Nash1, Dan Lin3, Kathleen Binns2, Clark Wells2, Rob Ingham2, Terry Kubiseski2, Bernard Liu1, Matt Smith2,3, Ivan Blasutig2,3, Maria Sierra1, Caesar Lim2,3, Michael Arc1, Jim Fawcett2 and Tony Pawson2,3.
1. Ben May Institute for Cancer Research, The University of Chicago, Chicago, Illinois, 60637, USA
2. Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
3. Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
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