 EVH1 Domain | | Class:Pro-rich binding | Structure:
| Domain binding and function:
The EVH1 domain is a protein module of ~115 amino acids found in a number of scaffolding proteins that mediate the assembly of multiprotein complexes involved in control of the actin cytoskeleton or in signal transduction in postsynaptic compartments. This domain was originally identified at the N-terminus of the Drosophila protein Enabled (Ena), its mammalian counterpart (Mena) and the closely related protein Vasp (hence the term Ena/Vasp Homology domain 1). EVH1 domains are also found in an additional member of the Mena family, Evl, in the WASP docking protein that is affected by mutations that cause the immunodeficiency Wiskott-Aldrich syndrome, and in the Homer family of synaptic proteins that interact with group 1 metabotropic glutamate receptors. EVH1 domains can be divided into two classes based on their proline-rich ligands. The class I EVH1 domains including the Ena/Vasp proteins recognize a FPxΦP motif, whereas the class II family of postsynaptic receptor-associated proteins recognize PPxxF motifs. These motifs are commonly found in components of the cytoskeleton, such as Vinculin and Zyxin, as well as in the ActA protein of the pathogenic bacterium Listeria monocytogenes, which regulates bacterial motility by controling actin polymerization in the infected cell. | Examples of Proteins: | EVH1 Domain Proteins |
| Binding Partners | Motifs
| Links
| | Class I: Ena/VASP |
| Vinculin, Zyxin, ActA | FPxΦP |
| Class II: Homer-Ves1
|
| mGluR, IP3R, RyR
| PPxxF
|
| | Mena (Mammalian Ena) |  | Zyxin, Vinculin cellular cytokeletal proteins ActA (L. monocytogenes) |
| ELM | | Homer synaptic docking protein | | Group 1 metabotropic glutamate receptor Shank synaptic scaffolding protein |
| SMART | | | | |
| Pfam | | | | |
| GlobPlot | |  |
| Referenced in part on Cell Signaling Technology Website, Reference Section on Protein Domains. We gratefully acknowledge the following contributors: Piers Nash1, Dan Lin3, Kathleen Binns2, Clark Wells2, Rob Ingham2, Terry Kubiseski2, Bernard Liu1, Matt Smith2,3, Ivan Blasutig2,3, Maria Sierra1, Caesar Lim2,3, Michael Arc1, Jim Fawcett2 and Tony Pawson2,3.
1. Ben May Institute for Cancer Research, The University of Chicago, Chicago, Illinois, 60637, USA
2. Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
3. Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada |
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