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UEV Domain
Class:Ubiquitin processes

“The UEV domain of TSG101 bound to ubiquitin (red)”

Domain binding and function:
The UEV (Ubiquitin E2 variant) domain is ubiquitin binding domain of ~145 amino acids.   The structure of the UEV domain contains a characteristic α/β fold similar to the canonical E2 enzyme but has an additional N-terminal helix and lacks the two C-terminal helices. Found in TSG101/Vps23 proteins, the UEV interacts with a ubiquitin molecule and is essential for the trafficking of a number of ubiquitylated cargoes to MVBs.   Furthermore, the UEV domain can bind to Pro-Thr/Ser-Ala-Pro peptide ligands, a fact exploited by viruses such as HIV. Thus, the TSG101 UEV domain binds to the PTAP tetrapeptide motif in the viral Gag protein that is involved in viral budding.
Examples of Proteins: 
UEV proteins
Binding Partner
TSG101 Ubiquitin


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