Protein Interaction Domains
14-3-3 ADF: Actin-Depolymerizing Factor ANK: short 33 amino acid repeats (Ankyrin protein is composed almost entirely of these) ARM: Drosophila ARMadillo (the homolog of mammalian b-catenin) BAR: Bin/Amphiphysin/Rvs BEACH: `beige and CHS` (Chediak-Higashi Syndrome in mice) BH 1-4: eg in appoptosis inhibition proteins Bcl-2, Bcl-XL, Bcl-XW ...
BIR: Baculovirus IAP Repeat BRCT: eg C-terminal portion of the BRCA-1 BROMO: (recognizes acetylated lysine residues on the N-terminal tails of histones) BTB: (eg Broad-complex, Tramtrack and Bric-abrac Drosophila proteins) C1: (phorbol esters/diacylglycerol binding domain - indirect activation pkC) C2: Ca(2+)-binding motif CARD: (CAspase Recruitment Domains) CC: (Coiled-Coils oligomerization domains) CALM: (Clathrin Assembly Lymphoid Myeloid)
CH: (Calponin Homology domain) Chr: The Chromatin organization modifier (Chromo) domain CUE: Coupling of Ub to ER degradation domain DD: Death Domains - involved in apoptotic signal transduction DED: Death-Effector Domain ; found for example in inactive procaspases dep DH: The Dbl Homology or RhoGEF domain EF-hand: involved in binding intracellular calcium EH: Eps15(tyrosine kinase substrate)-Homology domain
ENTH: NH2-terminal homology domain; a membrane binding motif... EVH1: Ena/Vasp Homology domain 1 ; Drosophila protein Enabled (Ena), a mammalian counterpart (Mena) and related protein (Vasp) F-box: first described as a sequence motif found in cyclin-F FERM: originally described in four proteins: F for Band 4.1, E for Ezrin, R for Radixin, M for Moesin FF: two highly conserved phenylalanine (F) residues ; first identified in the murine splicing factor FBP11 FH2: Formin Homology-2 domains FHA: ForkHead Associated domain; originally identified as a conserved region of forkhead transcription factors FYVE: Fab-1, YGL023, Vps27, and EEA1 domain; a small, cysteine-rich Zn2+ binding domain GAT: GGA And Tom1 domains (capable of binding ubiquitin)
GEL: GELsolin/severin/villin homology domain GLUE: GRAM-like ubiquitin-binding in EAP45 GRAM: Glucosyltransferases, Rab-like gtp-ase Activators and Myotubularins domains GRIP: originally identified as a conserved C-terminal domain in a group of Golgi yeast and mammals proteins GYF: Glycine-tYrosine-Phenylalanine domain - capable of binding to proline-rich peptide sequences HEAT: Huntington Elongation factor 3 PR65/A A subunit TOR domain HECT: Homologous to the E6-AP Carboxyl Terminus catalytic domain IQ: approximately 25 amino acids length motif conforming to [I,L,V]QxxxRGxxx[R,K] LIM: first identified in three developmentally regulated transcription factors Lin-1, Isl-1, and Mec-3
LRR: Leucine-Rich Repeats domain MBT: Malignant brain tumor repeats domain MH1: MAD (MAX dimerizer) Homology 1 domain MH2: MAD Homology 2 domain (see also MH1) MIU: Motif Interacting with Ubiquitin domain NZF: Npl4 zinc finger domain PAS: Per-ARNT-Sim domains PB1: Phox and Bem1 domains PDZ: identified first in PSD95,DlgA and zo-1 (post synaptic density protein, Drosophila disc large tumor suppressor, zonula occuldens-1)
PH: Pleckstrin-Homology domains Polo-Box: found in the family of Polo-like kinases (plks) PTB: PhosphoTyrosine Binding domains PUF: Pumilio (PUF repeats) domains PWWP: proline-tryptophan-tryptophan-proline core motif PX: PhoX homology domains (belong to the family of phospholipid-binding domains) RGS: Regulator of G protein Signaling domain RING: a specialized type of Zn-finger consisting of 40 to 60 residues that binds two atoms of zinc SAM: Sterile Alpha Motif domain
SC: Shadow Chromo domain (see chromodomains Chr) SH2: Src Homology 2 domains SH3: Src Homology 3 domains SOCS: initialy identified in SOCS proteins (supressors of cytokine signaling family of proteins) SPRY: splA (of Dictyostelium) and ryanodine (of rabbit ) receptor START: Steroidogenic Acute Regulatory protein (StAR) related lipid Transfer SWIRM: implicated in chromatin remodeling and gene expression TIR: Toll/Interleukin-1 Receptor domains
TPR: tetratricopeptide repeat motif - loosely based around the consensus residues -W-LG-Y-A-F-A-P- TRAF: Tumor Necrosis Factor (TNF) receptor-associated factors tSNARE: soluble NSF attachment protein (SNAP) receptors TUBBY: first identified in the tubby protein implicated in mature-onset obesity TUDOR: originally identified in the Tudor protein (a posterior group gene) UBA: ubiquitin-associated domain UEV: Ubiquitin E2 variant UIM: ubiquitin-interacting motif VHLß: von Hippel-Lindau tumor suppressor protein (VHL) beta-domain
VHS: Vps27p, Hrs and STAM domain WD40: propeller-like structure with 7 blades composed each of a four-stranded anti-parallel ß-sheet WW: two conserved tryptophans (W) spaced 20-22 amino acids apart