Dynactome Project
Written by Pawson Lab   
The Dynactome Project brings together an international team of scientists to study protein dynamics at a systems level. The project will use state-of-the-art strategies to map out protein interactions within human cells, and define the aberrations that characterize malignancy at the systems level.
Although the information that defines cellular organization is ultimately contained within the genes, it is the products of these genes, namely RNA and protein, that actually perform the catalytic and structural functions through which cells are assembled and carry out their biological tasks. Conversely, diseases such as cancer are caused by mutations (that is to say alterations) in specific genes, but these have a detrimental effect because they modify the activities of regulatory proteins. Work over the last two decades, initiated in Canada, has led to the realization that proteins have a critical ability to interact with one another, and thereby assemble larger pathways and networks within the cell that are responsible for sophisticated cellular behaviour. We argue that many diseases, especially malignant cancers, result not only from specific changes to individual genes and proteins, but also from alterations in the entire cellular network. A key issue that makes this project challenging is that the cell’s protein interaction network changes in a dynamic fashion. We will use complementary approaches to analyze the dynamic protein interaction network (“dynactome”) in normal and malignant cells.
Further details on The Dynactome Project can be found at: http://dynactome.mshri.on.ca
Last Updated ( Thursday, 06 July 2006 )