Positive selection of tyrosine loss in metazoan evolution
Monday, 13 June 2011

Response to Comment on

Chris Soon Heng Tan,

Science 2011 May: 332: 917


Erwin M. Schoof, Pau Creixell, Adrian Pasculescu,Wendell A. Lim,Tony Pawson,Gary D. Bader, Rune Linding
Positive Selection of Tyrosine Loss in Metazoan Evolution

    Su et al. claim guanine-cytosine (GC) content variation can largely explain the observed tyrosine frequency variation, independent of adaptive evolution of cell-signaling complexity. We found that GC content variation, in the absence of selection for amino acid changes, can only maximally account for 38% of the observed tyrosine frequency variation. We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal.


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