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PWWP Domain

“PWWP Domain of Mammalian Dnmt3b”

Domain binding and function:
The PWWP domain was first identified upon characterizing a gene located in the Wolf-Hirschhorn syndrome (WHS) critical region. The translocated form of WHSC1 is involved in lymphoid multiple myeloma (MM) disease, also known as plasmacytoma.   The domain was designated PWWP based on its central core ‘proline-tryptophan-tryptophan-proline’.  Identified in some two-dozen proteins in the human genome, the PWWP domain is ~135 amino acid residues in length.  The N-terminal half of the PWWP domain exhibits a barrel-like five-stranded structure that resembles the SAND domain, while the C-terminal portion is made up of a five-helix bundle.  PWWP domains are found in eukaryotic proteins from yeast to mammals and are involved in DNA methylation, DNA repair and regulation of transcription.   The PWWP domain of Dnmt3b2 contains a basic surface that may play a role in DNA binding.
Examples of Proteins: 
PWWP proteins

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