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Axon Guidance |
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Written by Pawson Lab
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Our interest in mechanisms by which receptor-target interactions are regulated has recently focussed on
structural analysis of the autoinhibited EphB2 RTK, a representative of the largest family of mammalian
RTKs (Wybeng-Groot L., Baskin B., Ong. S.H., Tong J., Pawson T., and Sicheri F. (2001) Cell 106, 745-757). |
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Last Updated ( Tuesday, 28 February 2006 )
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Creating Switch-Like Responses |
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Written by Pawson Lab
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Recent work in our lab into mechanisms by which phosphorylation events can be utilized to regulate complex biological events has shown that multi-site phosphorylation of the CDK inhibitor, Sic1, sets a threshold for the onset of DNA replication and creates an ultrasensitive biological switch. (Reference: Nash, P., Tang, X., Orlicky, S., Chen, Q., Gertler, F., Mendenhall, M.D., Sicher, F., Pawson, T., and Tyers, M. (2001) Nature 414, 516-523.) |
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Last Updated ( Thursday, 02 March 2006 )
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Domains |
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Written by Pawson Lab
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An ever-increasing body of data suggests that proteins involved in the regulation of cellular events such as signal transduction, the cell cycle, protein trafficking, targeted proteolysis, cytoskeletal organization and gene expression are constructed in a modular fashion from a combination of interaction and catalytic domains. |
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Last Updated ( Tuesday, 28 February 2006 )
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Dynactome Project |
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Written by Pawson Lab
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The Dynactome Project brings together an international team of scientists to study protein dynamics at a systems level. The project will use state-of-the-art strategies to map out protein interactions within human cells, and define the aberrations that characterize malignancy at the systems level. |
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Last Updated ( Thursday, 06 July 2006 )
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Pars and Polarity |
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Written by Pawson Lab
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During development, cells must frequently divide in an asymmetric fashion, such that the two daughter cells are inherently different from one another, both to establish polarized tissues and to allow a single stem cell to generate several distinct mature cell types. |
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Last Updated ( Monday, 03 April 2006 )
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Specificity In Signal Transduction |
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Written by Pawson Lab
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What are the underlying biochemical mechanisms through which specificity is generated during signal transduction, and the means by which signaling molecules may act in combination to generate complex biological responses?
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Last Updated ( Tuesday, 28 February 2006 )
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Synthetic biology |
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Assuming proteins are assembled in a modular fashion, it follows that one can apply principles from modular systems engineering. Thus, by redesigning or reverse engineering of known modular proteins, new synthetic, modular and functional polypeptides could be constructed. By attempting this we can fully explore whether modules have served as building blocks in the evolution of protein function, something that has been suggested from bioinformatics and experimental analysis, but remains to be substantiated for reverse engineered proteins. Such experiments will address the extent to which biological systems actually conform to this paradigm of modularity.
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Last Updated ( Saturday, 09 September 2006 )
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Research