 UIM Domain | |
|
| Class:Ubiquitin processes | |
|
Structure:
| |
|
Domain binding and function:
The MIU (Motif Interacting with Ubiquitin) domain binds to ubiquitin in a manner almost identical to that of the UIM:Ub interaction, although in the opposite orientation.
Similar to UIM domains, a critical Ala residue is required for binding to Ub. MIU-containing proteins have been reported to bind to polyUb chains linked through lysine-48 or lysine-63 of ubiquitin. The identification of MIU domains in proteins such as Myosin VI and Rabex-5 support their role in ubiquitin-dependant vesicular trafficking.
| |
|
Examples of Proteins:
| MIU proteins |
|
Binding Partner |
| Myosin VI |  |
mono- and polyubiquitin |
| RNF168 | |
mono- and polyubiquitin |
| Rabex-5 | |
mono- and polyubiquitin |
| |
 |
|
Referenced in part on Cell Signaling Technology Website, Reference Section on Protein Domains. We gratefully acknowledge the following contributors:
Piers Nash1, Dan Lin3, Kathleen Binns2, Clark Wells2, Rob Ingham2, Terry Kubiseski2, Bernard Liu1, Matt Smith2,3, Ivan Blasutig2,3, Maria Sierra1, Caesar Lim2,3, Michael Arc1, Jim Fawcett2 and Tony Pawson2,3.
1. Ben May Institute for Cancer Research, The University of Chicago, Chicago, Illinois, 60637, USA
2. Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
3. Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
| |
|
