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HEAT Domain
Structure:

No ImageThe HEAT domain consists of repeats of two anti-parallel α-helices and two turns arranged about a common axis. These repeats are linked by flexible inter-unit loops. A signature motif of the HEAT repeats is the presence of conserved Asp and Arg residues at positions 19 and 25, respectively.
Structure Reference:
Groves, M.R. et al. (1999) Cell. 96(1): 99-110.
Vetter, I.R. et al. (1999) Cell. 97(5): 635-646. PDB: 1IBR.
Domain binding and function:
The protein domain HEAT (Huntington, Elongation Factor 3, PR65/A, TOR) was derived from four diverse eukaryotic proteins. The HEAT domain consists of repeats of ~47 residues that form two anti-parallel α-helices and two turns arranged about a common axis.  A signature motif of the HEAT repeats is the presence of conserved Asp and Arg residues at positions 19 and 25, respectively.  Similarities between HEAT and Armadillo (ARM) repeat families are found in the conserved residues that form the hydrophobic cores.   In constrast to ARM repeats, HEAT repeats are more variable in length, amino acid sequence and 3D-structure.  Family of HEAT repeats are divided into three classes: IMB, AAA and ADB based on similarities.   HEAT containing proteins are found in proteins such as importins and exportins that bind Ran-GTP implicating their role in cargo transport.   A substantial number of HEAT repeats have been detected in proteins involved in translation including eIF4Gs, p97/DAP5, Paip-1, GCN1 and FRAP/mTOR.  
Examples of Proteins: 
HEAT domain proteins
Binding partners
PA200


Ecm29


PR65/A PP2Ac and B subunits
TOR


NOC3P


Importins β1 Ran-GTP
Importins β2


SAP155


Cse1, exportin


eIF5


eIF4GII eIF5




 
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