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Positive selection of tyrosine loss in metazoan evolution |
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Monday, 13 June 2011 |
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Response to Comment on Chris Soon Heng Tan, Science 2011 May: 332: 917 10.1126/science.1188535 Erwin M. Schoof, Pau Creixell, Adrian Pasculescu,Wendell A. Lim,Tony Pawson,Gary D. Bader, Rune Linding“Positive Selection of Tyrosine Loss in Metazoan Evolution”
Su et al. claim guanine-cytosine (GC) content variation can largely explain the observed tyrosine frequency variation, independent of adaptive evolution of cell-signaling complexity. We found that GC content variation, in the absence of selection for amino acid changes, can only maximally account for 38% of the observed tyrosine frequency variation. We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal.
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Last Updated ( Wednesday, 10 August 2011 )
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