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NZF Domain
Class:Ubiquitin processes

Domain binding and function:
The NZF domain (Npl4 zinc finger) is a compact zinc-binding module found in many proteins that function in ubiquitin-dependent processes.   Present in more than 100 proteins, NZF domains conform to the consensus sequence: x(4)-W-x-C-x(2)-C-x(3)-N-x(6)-C-x(2)-C-x(5), with many more proteins containing recognizable variants of the NZF motif.  Consisting of ~35 amino acids, the NZF domain forms a compact module composed of four antiparallel β-strands linked by three ordered loops and organized about a rubredoxin-like Zn(Cys)4 metal-binding site.  While many NZF domains have shown to bind mono- and polyubiquitin, not all NZF domains appear capable of binding ubiquitin.
Examples of Proteins: 
NZF proteins
Binding Partner
RanBP2 Ubiquitin
Vps36/ESCRT-II Ubiquitin
Npl4 zinc finger Ubiquitin

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