 NZF Domain | |
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| Class:Ubiquitin processes | |
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Structure:
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Domain binding and function:
The NZF domain (Npl4 zinc finger) is a compact zinc-binding module found in many proteins that function in ubiquitin-dependent processes. Present in more than 100 proteins, NZF domains conform to the consensus sequence: x(4)-W-x-C-x(2)-C-x(3)-N-x(6)-C-x(2)-C-x(5), with many more proteins containing recognizable variants of the NZF motif. Consisting of ~35 amino acids, the NZF domain forms a compact module composed of four antiparallel β-strands linked by three ordered loops and organized about a rubredoxin-like Zn(Cys)4 metal-binding site. While many NZF domains have shown to bind mono- and polyubiquitin, not all NZF domains appear capable of binding ubiquitin.
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Examples of Proteins:
| NZF proteins |
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Binding Partner |
| RanBP2 |  |
Ubiquitin |
| Vps36/ESCRT-II | |
Ubiquitin |
| Npl4 zinc finger | |
Ubiquitin |
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Referenced in part on Cell Signaling Technology Website, Reference Section on Protein Domains. We gratefully acknowledge the following contributors:
Piers Nash1, Dan Lin3, Kathleen Binns2, Clark Wells2, Rob Ingham2, Terry Kubiseski2, Bernard Liu1, Matt Smith2,3, Ivan Blasutig2,3, Maria Sierra1, Caesar Lim2,3, Michael Arc1, Jim Fawcett2 and Tony Pawson2,3.
1. Ben May Institute for Cancer Research, The University of Chicago, Chicago, Illinois, 60637, USA
2. Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
3. Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
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