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MBT repeat Domain
Class:Other: Methyl-lysine binding

Domain binding and function:
Malignant brain tumor (MBT)  repeats have been implicated as methyl-lysine binding modules that bind to methylated peptides from the amino-terminal tails of histones H3 and H4. MBT repeats are ~100 amino acid residues in length and are found in the proteome of most metazoans. Each repeat consists of a globular core and an extended arm. Interdigitation between the arms of the three MBT repeats of the polycomb group protein h-l(3)mbt results in a three-leaved propeller with a hollow central cavity. Each repeat harbors a hydrophobic ligand-binding pocket.
Examples of Proteins: 
MBT proteins
Binding Partner
CGI-72 monomethylated histone H3 lysine-4 or H4 lysine-20
L(3)MBTL Histone H3 monomethylated lysine-4


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